Description
Following the introduction of the concept of selective photothermolysis, laser treatment has been developed to treat various skin discolorations. However, it is common for laser treatment of cutaneous pigmented lesions in Asian patients to cause worsening of the pigmentation. The QSNY laser is known to be an effective and safe treatment for pigmented disorders, although there is a likelihood of recurrence in Asian populations, with side effects such as PIH and mottled hypopigmentation [
8-
10].
Since the introduction of PSLs, many clinical studies have shown better results in the removal of tattoos and treatment of various pigmented diseases compared to NSLs [
2-
7,
11]. PSLs treat discolorations based on the same principle as NSLs, but with a pulse width one thousand times shorter. This produces an extremely high peak power with the same energy, thus enabling reduction of the photothermal effect while increasing the photomechanical effect (photo-osmosis) [
3]. This results in significantly smaller pigment particles that are more quickly removed by macrophages, coupled with less heat transfer to the surrounding tissue. Therefore, the total duration and number of sessions can be shortened in the treatment of pigmented disorders and use of the PSL can therefore reduce adverse events such as PIH [
5,
6].
In our previous study, we evaluated Korean patients (Fitzpatrick skin type IV) with Ota’s nevus treated with a nanosecond-domain QSNY laser. Moderate improvement (26%-50%) was reported after 4.1 ± 2.0 treatment sessions at a wavelength of 1,064-nm, 2.5 J/cm
2, 5-10 nanoseconds, 7-8 mm spot size, and 10 Hz frequency [
12]. In the present study, fair improvement (25%-49%) was observed after 3.70 ± 2.16 sessions with the PSNY laser with a mean fluence of 2.45 ± 1.14 J/cm
2 (1,064-nm, 0.65-4.00 J/cm
2, 5-9 mm spot size, 5-10 Hz). Thus, fewer treatment sessions were required for the PSNY laser compared to the QSNY laser to achieve a similar clinical improvement.
The treatment of melasma is challenging due to its refractory and recurrent nature, especially in Asian skin types. Based on the theory of selective photothermolysis proposed by Anderson and Parrish [
13], QS laser treatment such as QSNY, QS alexandrite, and QS ruby has been widely used for treating melasma with variable degrees of success [
9]. Recently, the low-fluence, large-spot size application of the nanosecond-domain 1,064-nm QSNY, called laser toning, has been widely used for the treatment of melasma in Asian skin [
10]. However, the recurrence rate is high, and rebound hyperpigmentation and mottled hypopigmentation are common side effects. Moreover, many treatment sessions are required. According to a previous clinical study, moderate (25%-50%) clearance of melasma lesions was observed after three to four QSNY laser treatment sessions. The parameters used were a spot size of 8.5 mm in diameter, a fluence of 2.6-3.6 J/cm
2, and a repeated frequency of 2 Hz [
14].
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